Iturbe, a current Paraguay international, will join the Liga MX side on a temporary basis until 30 June 2018.
As part of the agreement, Tijuana (often referred to as 'Xolos') must make the signing permanent upon the achievement of certain sporting targets.
Iturbe, 24, joined the Giallorossi from Hellas Verona in the summer of 2014. He has gone on to make 68 appearances for the club, scoring five goals.
He spent the second half of last season on loan at Torino.
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