Roma, who will enter at the last-16 stage of the competition, will face one of Spezia, Pordenone, Parma or Lecce in the tie - which will take place at the start of the New Year.
Serie A champions Inter Milan are the other top-seeded side in the Giallorossi's quarter of the draw, while either AC Milan or Lazio could feasibly await in the semi-finals of the competition.
Juventus, Atalanta and Napoli are all on the other side of the draw - meaning a match against any of those is only possible if Jose Mourinho's charges reach the competition's final in May.
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