Mandzukic headed home 10 minutes before half-time, a moment that ended up deciding things at the Juventus Stadium.
Robin Olsen made a number of fine saves for the Giallorossi - who had their best chances in the second half, with Bryan Cristante going close in the final stages.
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The Giallorossi have two more games in 2018, as they host Sassuolo at the Stadio Olimpico on Wednesday and then travel to face Parma next weekend.
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