Valentin Mihaila and Hernani scored the goals in either half for the hosts, who grabbed a vital three points at the Stadio Ennio Tardini in their battle against relegation.
But the result will be a significant blow for the Giallorossi, as they missed an opportunity to apply pressure in the race for a top-four finish.
If there were any positives to take, then perhaps one was a debut for January signing Bryan Reynolds - as the American played 30 minutes in the second half as the side chased a route back into the match.
Paulo Fonseca's side are back in action on Thursday - they face Shakhtar Donetsk in the second leg of their Europa League last-16 tie.
PARMA 2-0 ROMA
SCORERS: Mihaila (10'), Hernani (55' p.)
ROMA (3-4-2-1): Pau Lopez; Mancini, Ibanez, Kumbulla (Cristante); Peres (Reynolds), Pellegrini (Mayoral), Villar (Diawara), Spinazzola; Pedro (Perez), El Shaarawy; Dzeko
Unused subs: Mirante, Fuzato, Karsdorp, Santon, Fazio, Pastore, Calafiori
PARMA (4-3-3): Sepe; Conti (Laurini), Bani, Osorio, Giu. Pezzella; Hernani (Grassi), Brugman, Kurtic; Man, Pellé (Zirkzee), Mihaila (Karamoh)
Unused subs: Colombi, Cyprien, Solomon, Zagaritis, Bruno Alves, Busi, Brunetta, Dierckx
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